A novel role of topical iodine in skin: Activation of the Nrf2 pathway

Normal keratinization in a spontaneously immortalized aneuploid human keratinocyte cell line.

Petra Boukamp, R T Petrussevska, Dirk Breitkreutz et al. · The Journal of Cell Biology · 1988 · 4.1K citations · Full text

Skin Development, Cell Division, Cutaneous Biology +11

An Nrf2/Small Maf Heterodimer Mediates the Induction of Phase II Detoxifying Enzyme Genes through Antioxidant Response Elements

Ken Itoh, Tomoki Chiba, Satoru Takahashi et al. · Biochemical and Biophysical Research Communications · 1997 · 3.9K citations

Reductive Stress, Biochemistry, Nrf2/small Maf Heterodimer +10

Keap1 represses nuclear activation of antioxidant responsive elements by Nrf2 through binding to the amino-terminal Neh2 domain

Ken Itoh, Nobunao Wakabayashi, Yasutake Katoh et al. · Genes & Development · 1999 · 3.5K citations · Full text

Lipid Peroxidation, Molecular Biology, Redox Biology +18

LXXIII.—Oxidation of tartaric acid in presence of iron

H. J. H. Fenton · Journal of the Chemical Society Transactions · 1894 · 3.1K citations

Tartaric Acid, Engineering, Biochemistry +11

Oxidative Stress Sensor Keap1 Functions as an Adaptor for Cul3-Based E3 Ligase To Regulate Proteasomal Degradation of Nrf2

Akira Kobayashi, Moon-Il Kang, Hiromi Okawa et al. · Molecular and Cellular Biology · 2004 · 2.2K citations · Full text

Molecular Biology, Redox Biology, Oxidative Stress +18