Exposure to high levels of fumarate and succinate leads to apoptotic cytotoxicity and altered global DNA methylation profiles in vitro

Succinate is an inflammatory signal that induces IL-1β through HIF-1α

Gillian M. Tannahill, Annie M. Curtis, Juraj Adamik et al. · Nature · 2013 · 4K citations · Full text

Life Sciences, Immunology, Molecular Medicine +12

Succinate links TCA cycle dysfunction to oncogenesis by inhibiting HIF-α prolyl hydroxylase

Mary Selak, Sean M. Armour, Elaine D. MacKenzie et al. · Cancer Cell · 2005 · 2.1K citations · Full text

Medicine, Cancer Biology, Oncology +14

Absolute metabolite concentrations and implied enzyme active site occupancy in Escherichia coli

Bryson D. Bennett, Elizabeth Kimball, Melissa Gao et al. · Nature Chemical Biology · 2009 · 1.9K citations · Full text

Life Sciences, Biochemistry, Microbiology +16

Germline mutations in FH predispose to dominantly inherited uterine fibroids, skin leiomyomata and papillary renal cell cancer

Shamima Rahman, S. E. Olpin · Nature Genetics · 2002 · 1.6K citations

Medicine, Genetics, Molecular Genetics +16

Persistent inhibition of cell respiration by nitric oxide: Crucial role of <i>S</i> -nitrosylation of mitochondrial complex I and protective action of glutathione

Emilio Clementi, Guy C. Brown, Martin Feelisch et al. · Proceedings of the National Academy of Sciences · 1998 · 850 citations · Full text

Life Sciences, Biochemistry, Physiology +17