Characterization of the cell-free DNA released by cultured cancer cells

Abel J. Bronkhorst, Johannes F. Wentzel, Janine Aucamp, +3

Biochimica et Biophysica Acta (BBA) - Molecular Cell Research

Tumor BiologyHuman CellMedicineNatural SciencesDna Analysis +8

Interactions of the antimicrobial peptide nisin Z with conventional antibiotics and the use of nanostructured lipid carriers to enhance antimicrobial activity

Angélique Lewies, Johannes F. Wentzel, Anine Jordaan, +2

International Journal of Pharmaceutics

NanomedicineConventional AntibioticsEngineeringNanostructured Lipid CarriersAntimicrobial Activity +7

The antimicrobial peptide nisin Z induces selective toxicity and apoptotic cell death in cultured melanoma cells

Angélique Lewies, Johannes F. Wentzel, Hayley Christy Miller, +1

Biochimie

Reactive Nitrogen SpecieNitrosative StressApoptosisImmunologyApoptotic Cell Death +10

Assessing the DNA methylation status of single cells with the comet assay

Johannes F. Wentzel, Chrisna Gouws, Cristal Huysamen, +3

Analytical Biochemistry

ChromatinDna Methylation StatusMedicineGeneticsDna Methylation +11

Evaluation of the cytotoxic properties, gene expression profiles and secondary signalling responses of cultured cells exposed to fumonisin B1, deoxynivalenol and zearalenone mycotoxins

Johannes F. Wentzel, Martani Lombard, Du Plessis, +1

Archives of Toxicology

Cultured CellsSecondary Signalling ResponsesMedicineMycotoxin FormationZearalenone Mycotoxins +10

Exposure to high levels of fumarate and succinate leads to apoptotic cytotoxicity and altered global DNA methylation profiles in vitro

Johannes F. Wentzel, Angélique Lewies, Abel J. Bronkhorst, +3

Biochimie

MedicineGeneticsDna MethylationEpigenetic ChangeApoptotic Cytotoxicity +11

Sequence analysis of cell-free DNA derived from cultured human bone osteosarcoma (143B) cells

Abel J. Bronkhorst, Johannes F. Wentzel, Vida Ungerer, +5

Tumor Biology

CytogeneticsGeneticsDna AnalysisEpigeneticsTumor Biology +24

Synthesis, in vitro antimalarial activities and cytotoxicities of amino-artemisinin-ferrocene derivatives

Christo de Lange, Dina Coertzen, Frans J. Smit, +5

Bioorganic & Medicinal Chemistry Letters

Medicinal ChemistryAmino-artemisinin-ferrocene DerivativesBiochemistryAntiparasitic AgentNatural Sciences +4

Synthesis, antimalarial activities and cytotoxicities of amino-artemisinin-1,2-disubstituted ferrocene hybrids

Christo de Lange, Dina Coertzen, Frans J. Smit, +5

Bioorganic & Medicinal Chemistry Letters

Medicinal ChemistryAntiparasitic AgentAmino-artemisinin-1,2-disubstituted Ferrocene HybridsPharmacologyPharmaceutical Chemistry +1

Using a medium-throughput comet assay to evaluate the global DNA methylation status of single cells

Angélique Lewies, Etresia van Dyk, Johannes F. Wentzel, +1

Frontiers in Genetics

Dna DamageEpigenetic ChangeGeneticsDna MethylationDna Analysis +18