A first-in-human Phase 1 study of epirubicin-conjugated polymer micelles (K-912/NC-6300) in patients with advanced or recurrent solid tumors

Risk Factors for Doxorubicin-lnduced Congestive Heart Failure

Daniel D. Von Hoff · Annals of Internal Medicine · 1979 · 2.4K citations

Drug Safety, Potential Risk Factors, Heart Failure +13

Congestive heart failure in patients treated with doxorubicin

Sandra M. Swain, Fredrick S. Whaley, Michael S. Ewer · Cancer · 2003 · 2.2K citations · Full text

Preparation and Biological Characterization of Polymeric Micelle Drug Carriers with Intracellular pH-Triggered Drug Release Property:  Tumor Permeability, Controlled Subcellular Drug Distribution, and Enhanced in Vivo Antitumor Efficacy

Younsoo Bae, Nobuhiro Nishiyama, Shigeto Fukushima et al. · Bioconjugate Chemistry · 2004 · 731 citations

Tumoritropic and lymphotropic principles of macromolecular drugs.

Hiroshi Maeda, Yasuhiro Matsumura · PubMed · 1989 · 580 citations

Medicinal Chemistry, Mw 16, Drug Targeting +13

Anthracycline-induced cardiotoxicity and the cardiac-sparing effect of liposomal formulation.

Atiar M. Rahman, Syed Wamique Yusuf, Michael S. Ewer · PubMed · 2007 · 256 citations

Cardiovascular Pharmacology, Pharmacotherapy, Cardiovascular Toxicity +19