Synthesis and bioevaluation of 2-phenyl-5-methyl-2H-1,2,3-triazole-4-carboxylic acid/carbohydrazide derivatives as potent xanthine oxidase inhibitors

Abstract

A series of 2-phenyl-5-methyl-2<italic>H</italic>-1,2,3-triazole-4-carboxylic acids/carbohydrazides as analogues of febuxostat were synthesized and evaluated for their <italic>in vitro</italic> xanthine oxidase (XO) inhibitory activity.