Concepedia

Exploration of novel piperazine or piperidine constructed non-covalent peptidyl derivatives as proteasome inhibitors

Rangxiao Zhuang, Lixin Gao, Xiaoqing Lv, Jianjun Xi, Li Sheng, Yanmei Zhao, Ruoyu He, Xiaobei Hu, Yidan Shao, Xuwang Pan,

European Journal of Medicinal Chemistry · 2016 · 13 citations · 7 references

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References

7

Proposed role of ATP in protein breakdown: conjugation of protein with multiple chains of the polypeptide of ATP-dependent proteolysis.

Avram Hershko, Aaron Ciechanover, H Heller et al. · Proceedings of the National Academy of Sciences · 1980 · 747 citations · Full text

, , +15

U.S. Food and Drug Administration Approval: Carfilzomib for the Treatment of Multiple Myeloma

Thomas M. Herndon, Albert Deisseroth, Edvardas Kaminskas et al. · Clinical Cancer Research · 2013 · 241 citations

, , +17

Structure- and function-based design of Plasmodium-selective proteasome inhibitors

Hao Li, Anthony J. O’Donoghue, Wouter A. van der Linden et al. · Nature · 2016 · 240 citations

, , +13

Characterization of a new series of non-covalent proteasome inhibitors with exquisite potency and selectivity for the 20S β5-subunit

Christopher Blackburn, Kenneth M. Gigstad, Paul Hales et al. · Biochemical Journal · 2010 · 146 citations · Full text

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Prion-mediated neurodegeneration is associated with early impairment of the ubiquitin–proteasome system

Chris McKinnon, Rob Goold, Ralph André et al. · Acta Neuropathologica · 2015 · 68 citations · Full text

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