Publication | Open Access

A structure-guided optimization of pyrido[2,3-d]pyrimidin-7-ones as selective inhibitors of EGFRL858R/T790M mutant with improved pharmacokinetic properties

Medicinal ChemistryDrug TargetEgfrl858r/t790m MutantBiochemistryMedicineNatural SciencesRational Drug DesignStructure-guided OptimizationPharmacological AgentSelective InhibitorsPharmacotherapyDrug DevelopmentChemical BiologyPharmacologyPharmaceutical ChemistryDrug Discovery