Computation of Octanol−Water Partition Coefficients by Guiding an Additive Model with Knowledge

Tiejun Cheng, Yuan Zhao, Xun Li, +6

Journal of Chemical Information and Modeling

CircRNA-ENO1 promoted glycolysis and tumor progression in lung adenocarcinoma through upregulating its host gene ENO1

Jiayu Zhou, Shizhen Zhang, Zhoumiao Chen, +3

Cell Death and Disease

Identification of COUP-TFII Orphan Nuclear Receptor as a Retinoic Acid–Activated Receptor

Schoen W Kruse, Kelly Suino-Powell, X. Edward Zhou, +8

PLoS Biology

Retinoic AcidsMolecular BiologyHelix Alpha10Transcriptional RegulationSignaling Pathway +15

ROR-γ drives androgen receptor expression and represents a therapeutic target in castration-resistant prostate cancer

Junjian Wang, June X. Zou, Xiaoqian Xue, +15

Nature Medicine

UrologyRor-γ DrivesMedicineHormonal ReceptorPharmacology +5

Identification and Mechanism of 10-Carbon Fatty Acid as Modulating Ligand of Peroxisome Proliferator-activated Receptors

Raghu R.V. Malapaka, Sok Kean Khoo, Jifeng Zhang, +12

Journal of Biological Chemistry

Lipid Peroxidation10-Carbon Fatty AcidOxidative StressMetabolic SyndromeMolecular Pharmacology +16

Discovery and Optimization of 3-(2-(Pyrazolo[1,5-<i>a</i>]pyrimidin-6-yl)ethynyl)benzamides as Novel Selective and Orally Bioavailable Discoidin Domain Receptor 1 (DDR1) Inhibitors

Mingshan Gao, Lei Duan, Jinfeng Luo, +8

Journal of Medicinal Chemistry

Drug TargetChemoprevention StrategyPharmacotherapyPharmaceutical ChemistryMedicinal Chemistry +17

Small-molecule targeting of a diapophytoene desaturase inhibits S. aureus virulence

Feifei Chen, Hongxia Di, Youxin Wang, +12

Nature Chemical Biology

Natural SciencesVirulence FactorMolecular BiologySelective ToxicitySmall-molecule Targeting +7

Adipocyte-derived lactate is a signalling metabolite that potentiates adipose macrophage inflammation via targeting PHD2

Tianshi Feng, Xuemei Zhao, Ping Gu, +16

Nature Communications

ImmunologyMetabolic RemodelingInsulin SignalingOxidative StressObesity +22

Design, Synthesis, and in Vitro Biological Evaluation of 1<i>H</i>-1,2,3-Triazole-4-carboxamide Derivatives as New Anti-influenza A Agents Targeting Virus Nucleoprotein

Huimin Cheng, Junting Wan, Meng‐I Lin, +8

Journal of Medicinal Chemistry

DDX17‐regulated alternative splicing that produced an oncogenic isoform of PXN‐AS1 to promote HCC metastasis

Hong‐Zhong Zhou, Li Fan, Sheng‐Tao Cheng, +11

Hepatology