Xiao-E Yan

Structural Basis of AZD9291 Selectivity for EGFR T790M

Xiao-E Yan, Pelin Ayaz, Sujie Zhu et al. · Journal of Medicinal Chemistry · 2020 · 113 citations

Drug Target, Engineering, Biomolecular Structure Prediction +17

Structural and biochemical studies of the PDGFRA kinase domain

Ling Liang, Xiao-E Yan, Yuxin Yin et al. · Biochemical and Biophysical Research Communications · 2016 · 56 citations

Pdgfra Kinase Domain, Signal Transduction, Molecular Physiology +6

Ibrutinib targets mutant-EGFR kinase with a distinct binding conformation

Aoli Wang, Xiao-E Yan, Hong Wu et al. · Oncotarget · 2016 · 47 citations · Full text

Ibrutinib selectively and irreversibly targets EGFR (L858R, Del19) mutant but is moderately resistant to EGFR (T790M) mutant NSCLC Cells

Hong Wu, Aoli Wang, Wei Zhang et al. · Oncotarget · 2015 · 46 citations · Full text

Novel Therapy, Medicine, Receptor Tyrosine Kinase +14

A structure-guided optimization of pyrido[2,3-d]pyrimidin-7-ones as selective inhibitors of EGFRL858R/T790M mutant with improved pharmacokinetic properties

Lei Yu, Minhao Huang, Tianfeng Xu et al. · European Journal of Medicinal Chemistry · 2016 · 44 citations · Full text

Medicinal Chemistry, Drug Target, Egfrl858r/t790m Mutant +13