Concepedia

Design, synthesis and biological evaluation of 4,5-dibromo-N-(thiazol-2-yl)-1H-pyrrole-2-carboxamide derivatives as novel DNA gyrase inhibitors

Tihomir Tomašič, Matic Mirt, Michaela Barančoková, Janez Ilaš, Nace Zidar, Päivi Tammela, D. Kikelj

Bioorganic & Medicinal Chemistry · 2016 · 39 citations · 33 references

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33

Merck molecular force field. I. Basis, form, scope, parameterization, and performance of MMFF94

Thomas A. Halgren · Journal of Computational Chemistry · 1996 · 5.3K citations

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A Fast Flexible Docking Method using an Incremental Construction Algorithm

Matthias Rarey, Bernd Krämer, Thomas Lengauer et al. · Journal of Molecular Biology · 1996 · 2.8K citations

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DNA Gyrase Interaction with Coumarin-Based Inhibitors:  The Role of the Hydroxybenzoate Isopentenyl Moiety and the 5‘-Methyl Group of the Noviose

Daniel Lafitte, Valérie Lamour, Philippe Tsvetkov et al. · Biochemistry · 2002 · 327 citations

, , +13

Novel Dual-Targeting Benzimidazole Urea Inhibitors of DNA Gyrase and Topoisomerase IV Possessing Potent Antibacterial Activity: Intelligent Design and Evolution through the Judicious Use of Structure-Guided Design and Stucture−Activity Relationships

Paul S. Charifson, Anne‐Laure Grillot, Trudy H. Grossman et al. · Journal of Medicinal Chemistry · 2008 · 225 citations · Full text

, , +16

Placement of medium-sized molecular fragments into active sites of proteins

Matthias Rarey, S. Wefing, Thomas Lengauer · Journal of Computer-Aided Molecular Design · 1996 · 206 citations

, , +11