Bio-inspired engineering proteinosomes with a cell-wall-like protective shell by self-assembly of a metal-chelated complex

Abstract

A cell-wall-like shell is constructed around proteinosomes by coordination complexes of tannic acid and Fe³⁺, which endows the engineered proteinosomes with an enhanced Young's modulus of the membrane, protease resistant ability, EDTA-mediated release of loaded DNA, and electrostatic gated encapsulated enzyme activity, as well as antioxidant capacity.