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Publication | Closed Access

Calculated Conjugated Payload from Immunoassay and LC–MS Intact Protein Analysis Measurements of Antibody-Drug Conjugate

DOI

22

Citations

22

References

2016

Year

Brian Rago, Tracey Clark, Lindsay King, Jenny Zhang, L. Nathan Tumey, Fengping Li, Frank Barletta, Cong Wei, Mauricio Leal, Steve Hansel,
Bioanalysis

Abstract

PK profiles from LBA, ADC and calculated conjugated payload (DAR × monoclonal antibody) were in good agreement. We present a new tool for PK assessment of ADCs while also exploring ADC metabolism and DAR sensitivity of LBA ADC assay.

References

YearCitations

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