Mauricio Leal

A general approach to site-specific antibody drug conjugates

Feng Tian, Yingchun Lu, Anthony Manibusan et al. · Proceedings of the National Academy of Sciences · 2014 · 309 citations · Full text

Medicinal Chemistry, Biochemistry, Polymer-drug Conjugate +15

Interspecies Prediction of Human Drug Clearance Based on Scaling Data from One or Two Animal Species

Huadong Tang, Azher Hussain, Mauricio Leal et al. · Drug Metabolism and Disposition · 2007 · 136 citations

Long-term Tumor Regression Induced by an Antibody–Drug Conjugate That Targets 5T4, an Oncofetal Antigen Expressed on Tumor-Initiating Cells

Puja Sapra, Marc Damelin, John F. DiJoseph et al. · Molecular Cancer Therapeutics · 2012 · 78 citations · Full text

On translation of antibody drug conjugates efficacy from mouse experimental tumors to the clinic: a PK/PD approach

Nahor Haddish‐Berhane, Dhaval K. Shah, Dangshe Ma et al. · Journal of Pharmacokinetics and Pharmacodynamics · 2013 · 76 citations

Tumor Immunology, Mouse Experimental Tumors, Medicine +13

A Priori Prediction of Tumor Payload Concentrations: Preclinical Case Study with an Auristatin-Based Anti-5T4 Antibody-Drug Conjugate

Dhaval K. Shah, Lindsay E. King, Xiaogang Han et al. · The AAPS Journal · 2014 · 59 citations · Full text

Tumor Biology, Medicine, Pharmacology +10