Human pluripotent stem cell-derived acinar/ductal organoids generate human pancreas upon orthotopic transplantation and allow disease modelling - Concepedia

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Publication | Open Access

Human pluripotent stem cell-derived acinar/ductal organoids generate human pancreas upon orthotopic transplantation and allow disease modelling

DOI Full Paper Access

209

Citations

44

References

2016

Year

Meike Hohwieler, Anett Illing, Patrick Hermann, T. Mayer, Marianne Stockmann, Lukas Perkhofer, Tim Eiseler, Justin S. Antony, Martin C. Müller, Susanne Renz,

Abstract

Taken together, our platform provides novel opportunities to model pancreatic disease and development, screen for disease-rescuing agents and to test therapeutic procedures.

References

	Year	Citations
Gene set enrichment analysis: A knowledge-based approach for interpreting genome-wide expression profiles Aravind Subramanian, Pablo Tamayo, Vamsi K. Mootha, Proceedings of the National Academy of Sciences GeneticsGenomicsGene RecognitionBioinformatics DatabaseGene Expression Profiling	2005	54.5K
Single Lgr5 stem cells build crypt-villus structures in vitro without a mesenchymal niche Toshiro Sato, Robert G.J. Vries, Hugo J.G. Snippert, Nature Regenerative MedicineCell LineageCrypt-villus StructuresDevelopmental BiologyMedicine	2009	6.9K
Organoid Models of Human and Mouse Ductal Pancreatic Cancer Sylvia F. Boj, Chang‐Il Hwang, Lindsey A. Baker, Cell Tumor BiologyPancreatic CancerPathologyOrganoid ModelsMedicine	2014	2.1K
Production of pancreatic hormone–expressing endocrine cells from human embryonic stem cells Kevin A. D’Amour, Anne G. Bang, Susan Eliazer, Nature Biotechnology Embryo CultureEndocrine CellsEmbryonic Stem CellInduced Pluripotent Stem CellDevelopmental Biology	2006	1.9K
Pancreatic endoderm derived from human embryonic stem cells generates glucose-responsive insulin-secreting cells in vivo Evert Kroon, Laura A. Martinson, Kuniko Kadoya, Nature Biotechnology Regenerative MedicineInduced Pluripotent Stem CellDevelopmental BiologyPancreatic EndodermGlucose-responsive Insulin-secreting Cells	2008	1.8K
Reversal of diabetes with insulin-producing cells derived in vitro from human pluripotent stem cells Alireza Rezania, Jennifer E. Bruin, Payal Arora, Nature Biotechnology Regenerative MedicineInduced Pluripotent Stem CellDevelopmental BiologyMedicineDiabetes	2014	1.6K
A functional CFTR assay using primary cystic fibrosis intestinal organoids Johanna F. Dekkers, Caroline L. Wiegerinck, Hugo R. de Jonge, Nature Medicine InflammationFibrosisImmunologyGastroenterologyPathology	2013	977
Nephron organoids derived from human pluripotent stem cells model kidney development and injury Ryuji Morizane, Albert Q. Lam, Benjamin Freedman, Nature Biotechnology Adult Stem CellOrgan DevelopmentNephron OrganoidsRegenerative MedicineOrganoid Models	2015	901
Continuous cell supply from a Sox9-expressing progenitor zone in adult liver, exocrine pancreas and intestine Kenichiro Furuyama, Yoshiya Kawaguchi, Haruhiko Akiyama, Nature Genetics Cell LineageDevelopmental BiologyLiver PhysiologySox9-expressing Progenitor ZoneOrgan Development	2010	821
Modelling kidney disease with CRISPR-mutant kidney organoids derived from human pluripotent epiblast spheroids Benjamin Freedman, Craig R. Brooks, Albert Q. Lam, Nature Communications	2015	756

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