Concepedia

Human pluripotent stem cell-derived acinar/ductal organoids generate human pancreas upon orthotopic transplantation and allow disease modelling

Meike Hohwieler, Anett Illing, Patrick Hermann, T. Mayer, Marianne Stockmann, Lukas Perkhofer, Tim Eiseler, Justin S. Antony, Martin C. Müller, Susanne Renz,

Gut · 2016 · 209 citations · 44 references

DOIFull text

Open access

Abstract

Taken together, our platform provides novel opportunities to model pancreatic disease and development, screen for disease-rescuing agents and to test therapeutic procedures.

References

44

Gene set enrichment analysis: A knowledge-based approach for interpreting genome-wide expression profiles

Aravind Subramanian, Pablo Tamayo, Vamsi K. Mootha et al. · Proceedings of the National Academy of Sciences · 2005 · 54.5K citations · Full text

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Single Lgr5 stem cells build crypt-villus structures in vitro without a mesenchymal niche

Toshiro Sato, Robert G.J. Vries, Hugo J.G. Snippert et al. · Nature · 2009 · 6.9K citations

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Organoid Models of Human and Mouse Ductal Pancreatic Cancer

Sylvia F. Boj, Chang‐Il Hwang, Lindsey A. Baker et al. · Cell · 2014 · 2.1K citations · Full text

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Production of pancreatic hormone–expressing endocrine cells from human embryonic stem cells

Kevin A. D’Amour, Anne G. Bang, Susan Eliazer et al. · Nature Biotechnology · 2006 · 1.9K citations

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Pancreatic endoderm derived from human embryonic stem cells generates glucose-responsive insulin-secreting cells in vivo

Evert Kroon, Laura A. Martinson, Kuniko Kadoya et al. · Nature Biotechnology · 2008 · 1.8K citations

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