Human pluripotent stem cell-derived acinar/ductal organoids generate human pancreas upon orthotopic transplantation and allow disease modelling

Meike Hohwieler, Anett Illing, Patrick Hermann, +25

Gut

ATM Deficiency Generating Genomic Instability Sensitizes Pancreatic Ductal Adenocarcinoma Cells to Therapy-Induced DNA Damage

Lukas Perkhofer, Anna Schmitt, Maria Carolina Romero Carrasco, +22

Cancer Research

Modeling plasticity and dysplasia of pancreatic ductal organoids derived from human pluripotent stem cells

Markus Breunig, Jessica Merkle, Martin Wagner, +34

Cell stem cell

Tissue EngineeringRegenerative MedicinePancreatic Ductal OrganoidsInduced Pluripotent Stem CellDevelopmental Biology +10

Single-cell-resolved differentiation of human induced pluripotent stem cells into pancreatic duct-like organoids on a microwell chip

Sandra Wiedenmann, Markus Breunig, Jessica Merkle, +13

Nature Biomedical Engineering

Tissue EngineeringInduced Pluripotent Stem CellPluripotent Stem CellsEngineeringMedicine +9

A Dynamic Role of TBX3 in the Pluripotency Circuitry

Ronan Russell, Marcus M. Ilg, Qiong Lin, +18

Stem Cell Reports

Lineage PlasticityInduced Pluripotent Stem CellDevelopmental BiologyEngineeringCircuit Design +13

Mutations and variants of ONECUT1 in diabetes

Anne Philippi, Sandra Heller, Ivan G. Costa, +37

Nature Medicine

GeneticsDiabetesGenetic EpidemiologyDiabetes MellitusDisease Gene Identification +2

Hsp70 facilitates trans-membrane transport of bacterial ADP-ribosylating toxins into the cytosol of mammalian cells

Katharina Ernst, Johannes A. Schmid, Mattias Beck, +14

Scientific Reports

ToxinologyMolecular BiologyCell DeathCytoskeletonBinary Enterotoxins Clostridium +17

Tbx3 fosters pancreatic cancer growth by increased angiogenesis and activin/nodal-dependent induction of stemness

Lukas Perkhofer, Karolin Walter, Ivan G. Costa, +17

Stem Cell Research

Transcriptional changes and the role of ONECUT1 in hPSC pancreatic differentiation

Sandra Heller, Zhijian Li, Qiong Lin, +11

Communications Biology

CDKN2A-Mutated Pancreatic Ductal Organoids from Induced Pluripotent Stem Cells to Model a Cancer Predisposition Syndrome

Jessica Merkle, Markus Breunig, Maximilian Schmid, +13

Cancers