Human pluripotent stem cell-derived acinar/ductal organoids generate human pancreas upon orthotopic transplantation and allow disease modelling

Meike Hohwieler, Anett Illing, Patrick Hermann, +25

Gut

Perioperative or only adjuvant gemcitabine plus nab-paclitaxel for resectable pancreatic cancer (NEONAX)—a randomized phase II trial of the AIO pancreatic cancer group

Thomas Seufferlein, Waldemar Uhl, Marko Kornmann, +31

Annals of Oncology

Surgical OncologyPancreatic CancerPhase Ii TrialGastrointestinal OncologyMedicine +4

Loss of ATM accelerates pancreatic cancer formation and epithelial–mesenchymal transition

Ronan Russell, Lukas Perkhofer, Stefan Liebau, +15

Nature Communications

ATM Deficiency Generating Genomic Instability Sensitizes Pancreatic Ductal Adenocarcinoma Cells to Therapy-Induced DNA Damage

Lukas Perkhofer, Anna Schmitt, Maria Carolina Romero Carrasco, +22

Cancer Research

Modeling plasticity and dysplasia of pancreatic ductal organoids derived from human pluripotent stem cells

Markus Breunig, Jessica Merkle, Martin Wagner, +34

Cell stem cell

Tissue EngineeringRegenerative MedicinePancreatic Ductal OrganoidsInduced Pluripotent Stem CellDevelopmental Biology +10

Pancreatic cancer‐derived organoids – a disease modeling tool to predict drug response

Pierre‐Olivier Frappart, Karolin Walter, Johann Gout, +20

United European Gastroenterology Journal

Neoadjuvant plus adjuvant or only adjuvant nab-paclitaxel plus gemcitabine for resectable pancreatic cancer - the NEONAX trial (AIO-PAK-0313), a prospective, randomized, controlled, phase II study of the AIO pancreatic cancer group

Thomas J. Ettrich, Andreas W. Berger, Lukas Perkhofer, +15

BMC Cancer

Synergistic targeting and resistance to PARP inhibition in DNA damage repair-deficient pancreatic cancer

Johann Gout, Lukas Perkhofer, Mareen Morawe, +27

Gut

Inhaled and systemic heparin as a repurposed direct antiviral drug for prevention and treatment of COVID-19

Carina Conzelmann, Janis A. Müller, Lukas Perkhofer, +4

Clinical Medicine

A Prospective Feasibility Trial to Challenge Patient–Derived Pancreatic Cancer Organoids in Predicting Treatment Response

Alica K. Beutel, Lena Schütte, Jeanette Scheible, +13

Cancers