mTOR inhibition sensitizes ONC201-induced anti-colorectal cancer cell activity

Cancer statistics, 2014

Rebecca L. Siegel, Jiemin Ma, Zhaohui Zou et al. · CA A Cancer Journal for Clinicians · 2014 · 11.6K citations · Full text

Medicine, Oncology, Cancer Epidemiology +16

Dual Inactivation of Akt and ERK by TIC10 Signals Foxo3a Nuclear Translocation, TRAIL Gene Induction, and Potent Antitumor Effects

Joshua E. Allen, Gabriel Krigsfeld, Patrick A. Mayes et al. · Science Translational Medicine · 2013 · 344 citations

Life Sciences, Molecular Biology, Oncology +17

ONC201 kills solid tumor cells by triggering an integrated stress response dependent on ATF4 activation by specific eIF2α kinases

C. Leah B. Kline, A. Pieter J. van den Heuvel, Joshua E. Allen et al. · Science Signaling · 2016 · 203 citations

Medicine, Cancer Biology, Oncology +17

ATF4 induction through an atypical integrated stress response to ONC201 triggers p53-independent apoptosis in hematological malignancies

Jo Ishizawa, Kensuke Kojima, Dhruv Chachad et al. · Science Signaling · 2016 · 202 citations

Life Sciences, Molecular Biology, Oncology +17

Cytokines and BCR-ABL mediate suppression of TRAIL-induced apoptosis through inhibition of forkhead FOXO3a transcription factor

Saghi Ghaffari, Zainab Jagani, Claire Kitidis et al. · Proceedings of the National Academy of Sciences · 2003 · 141 citations · Full text

Life Sciences, Cell Biology, Oncology +17