Concepedia

C. Leah B. Kline

CL

21

Publications

1.2K

Citations

17

H-Index

2005

Active since

Affiliations

Penn State Milton S. Hershey Medical Center(Current)

Fox Chase Cancer Center

Oncoceutics (United States)

Pennsylvania State University

Massachusetts General Hospital

C. Leah B. Kline is an author at Penn State Milton S. Hershey Medical Center specializing in medicine, oncology, and tumor biology.

ORCID

Top concepts

Publications per year

2005–2018

21

Publications

21

ONC201 kills solid tumor cells by triggering an integrated stress response dependent on ATF4 activation by specific eIF2α kinases

C. Leah B. Kline, A. Pieter J. van den Heuvel, Joshua E. Allen et al. · Science Signaling · 2016 · 195 citations · Full text

Role of Dopamine Receptors in the Anticancer Activity of ONC201

C. Leah B. Kline, Marie D. Ralff, Amriti R. Lulla et al. · Neoplasia · 2017 · 121 citations · Full text

Small-Molecule NSC59984 Restores p53 Pathway Signaling and Antitumor Effects against Colorectal Cancer via p73 Activation and Degradation of Mutant p53

Shengliang Zhang, Lanlan Zhou, Bo Hong et al. · Cancer Research · 2015 · 106 citations · Full text

Preclinical evaluation of the imipridone family, analogs of clinical stage anti-cancer small molecule ONC201, reveals potent anti-cancer effects of ONC212

Jessica Wagner, C. Leah B. Kline, Marie D. Ralff et al. · Cell Cycle · 2017 · 79 citations · Full text

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Dose intensification of TRAIL-inducing ONC201 inhibits metastasis and promotes intratumoral NK cell recruitment

Jessica Wagner, C. Leah B. Kline, Lanlan Zhou et al. · Journal of Clinical Investigation · 2018 · 78 citations · Full text

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