Heat Transfer Analysis of an Optimized, Flexible Holder System for Freeze-Drying in Dual Chamber Cartridges Using Different State-of-the-Art PAT Tools

Mass and Heat Transfer in Vial Freeze-Drying of Pharmaceuticals: Role of the Vial

Michael J. Pikal, Michael L. Roy, Saroj Shah · Journal of Pharmaceutical Sciences · 1984 · 343 citations

Pharmacy, Food Science, Pharmaceutics +14

Use of laboratory data in freeze drying process design: heat and mass transfer coefficients and the computer simulation of freeze drying.

Pikal Mj · PubMed · 1985 · 200 citations

Agriculture, Food Science, Mechanical Engineering +17

Heat and mass transfer scale-up issues during freeze-drying, I: Atypical radiation and the edge vial effect

Shailaja Rambhatla, Michael J. Pikal · AAPS PharmSciTech · 2003 · 184 citations · Full text

Pharmacy, Chemical Engineering, Food Science +16

Freeze-Drying Process Design by Manometric Temperature Measurement: Design of a Smart Freeze-Dryer

Xiaolin Tang, Steven L. Nail, Michael J. Pikal · Pharmaceutical Research · 2005 · 168 citations

Agriculture, Food Science, Food Engineering +15

Evaluation of manometric temperature measurement as a method of monitoring product temperature during lyophilization.

Nathaniel Milton, Michael J. Pikal, Michael L. Roy et al. · PubMed · 1997 · 155 citations

Pharmacy, Food Science, Food Analysis +16