Nature · 2016 · 461 citations · 14 references
MedicineOncologyPharmacologyCancer PharmacologyMolecular OncologyTumor MicroenvironmentKidney CancerOncology PharmacologyRenal Cell CarcinomaRenal PharmacologyTumor Microenvironment ModulationHif-2 Alpha RegulationVascular Endothelial Growth Factor Inhibition
14
HIF-2α Promotes Hypoxic Cell Proliferation by Enhancing c-Myc Transcriptional Activity
John D. Gordan, Jessica A. Bertout, Cheng‐Jun Hu et al. · Cancer Cell · 2007 · 764 citations · Full text
Targeting renal cell carcinoma with a HIF-2 antagonist
Wenfang Chen, Haley Hill, Alana Christie et al. · Nature · 2016 · 723 citations
Medicine, Cancer Biology, Oncology +10
Tumour suppression by the human von Hippel-Lindau gene product
Othon Iliopoulos, Adam S. Kibel, Steven G. Gray et al. · Nature Medicine · 1995 · 716 citations
Inhibition of HIF2α Is Sufficient to Suppress pVHL-Defective Tumor Growth
Keiichi Kondo, William Y. Kim, Mirna Lechpammer et al. · PLoS Biology · 2003 · 604 citations · Full text
Medicine, Cancer Biology, Oncology +17
HIF-α Effects on c-Myc Distinguish Two Subtypes of Sporadic VHL-Deficient Clear Cell Renal Carcinoma
John D. Gordan, Priti Lal, Vijay R. Dondeti et al. · Cancer Cell · 2008 · 486 citations · Full text