On-target efficacy of a HIF-2α antagonist in preclinical kidney cancer models

HIF-2α Promotes Hypoxic Cell Proliferation by Enhancing c-Myc Transcriptional Activity

John D. Gordan, Jessica A. Bertout, Cheng‐Jun Hu et al. · Cancer Cell · 2007 · 750 citations · Full text

Transcriptional Regulation, C-myc Transcriptional Activity, Cell Regulation +6

Tumour suppression by the human von Hippel-Lindau gene product

Othon Iliopoulos, Adam S. Kibel, Steven G. Gray et al. · Nature Medicine · 1995 · 711 citations

Oncogenic Agent, Medicine, Tumor Suppressor +5

Targeting renal cell carcinoma with a HIF-2 antagonist

Wenfang Chen, Haley Hill, Alana Christie et al. · Nature · 2016 · 697 citations · Full text

Urology, Genitourinary Cancer, Renal Cell Carcinoma +4

Inhibition of HIF2α Is Sufficient to Suppress pVHL-Defective Tumor Growth

Keiichi Kondo, William Y. Kim, Mirna Lechpammer et al. · PLoS Biology · 2003 · 596 citations · Full text

Tumor Biology, Biallelic Inactivation, Systems Biology +14

HIF-α Effects on c-Myc Distinguish Two Subtypes of Sporadic VHL-Deficient Clear Cell Renal Carcinoma

John D. Gordan, Priti Lal, Vijay R. Dondeti et al. · Cancer Cell · 2008 · 476 citations · Full text

Tumor Biology, Urology, Hif-α Effects +7