Genomic correlates of response to immune checkpoint therapies in clear cell renal cell carcinoma

Diana Miao, Claire A. Margolis, Wenhua Gao, +23

Science

On-target efficacy of a HIF-2α antagonist in preclinical kidney cancer models

Hyejin Cho, Xinlin Du, James P. Rizzi, +9

Nature

UrologyOncologyHif-2α AntagonistGenitourinary CancerKidney Research +5

Inactivation of the PBRM1 tumor suppressor gene amplifies the HIF-response in VHL ^−/− clear cell renal carcinoma

Wenhua Gao, Wei Li, Tengfei Xiao, +2

Proceedings of the National Academy of Sciences

The KDM5A/RBP2 histone demethylase represses NOTCH signaling to sustain neuroendocrine differentiation and promote small cell lung cancer tumorigenesis

Matthew G. Oser, Amin H. Sabet, Wenhua Gao, +18

Genes & Development

De novo pyrimidine synthesis is a targetable vulnerability in IDH mutant glioma

Diana D. Shi, Milan R. Savani, Michael M. Levitt, +48

Cancer Cell

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Plasticity in the Absence of NOTCH Uncovers a RUNX2-Dependent Pathway in Small Cell Lung Cancer

Deli Hong, Erik H. Knelson, Yixiang Li, +16

Cancer Research

Binding of wogonin to human gammaglobulin

Yongchun Liu, Wenying He, Wenhua Gao, +2

International Journal of Biological Macromolecules

Signal TransductionG Protein-coupled ReceptorMedicineCell BiologyCell Signaling +1

Mechanisms of acquired resistance to rapalogs in metastatic renal cell carcinoma

Lana Hamieh, Toni K. Choueiri, Barbara Ogórek, +10

PLoS Genetics

UrologyGenitourinary CancerTumor HeterogeneityMedicineMetastatic Rcc +10

De Novo Pyrimidine Synthesis is a Targetable Vulnerability in IDH Mutant Glioma

Diana D. Shi, Milan R. Savani, Michael M. Levitt, +40