Targeting renal cell carcinoma with a HIF-2 antagonist

Wenfang Chen, Haley Hill, Alana Christie, +31

Nature

UrologyGenitourinary CancerRenal Cell CarcinomaAnti-cancer AgentMedicine +2

Antisense and Antigene Properties of Peptide Nucleic Acids

Jeffery C. Hanvey, Nancy J. Peffer, John Bisi, +12

Science

Peptide Nucleic AcidsNucleic Acid ChemistryProtein ExpressionT10 PnaNatural Sciences +12

On-target efficacy of a HIF-2α antagonist in preclinical kidney cancer models

Hyejin Cho, Xinlin Du, James P. Rizzi, +9

Nature

UrologyOncologyHif-2α AntagonistGenitourinary CancerKidney Research +5

Phase I Dose-Escalation Trial of PT2385, a First-in-Class Hypoxia-Inducible Factor-2α Antagonist in Patients With Previously Treated Advanced Clear Cell Renal Cell Carcinoma

Kevin D. Courtney, Jeffrey R. Infante, Elaine T. Lam, +9

Journal of Clinical Oncology

Peripheral EdemaTumor BiologyConclusion Pt2385UrologyGenitourinary Cancer +10

A Small-Molecule Antagonist of HIF2α Is Efficacious in Preclinical Models of Renal Cell Carcinoma

Eli M. Wallace, James P. Rizzi, Guangzhou Han, +19

Cancer Research

A Nucleic Acid Triple Helix Formed by a Peptide Nucleic Acid-DNA Complex

Laurie Betts, John A. Josey, James M. Veal, +1

Science

Crystal StructureDnaStructural BioinformaticsMolecular BiologyPolypurine Dna Strand +14

Fmoc mediated synthesis of Peptide Nucleic Acids

Stephen A. Thomson, John A. Josey, Rodolfo Cadilla, +8

Tetrahedron

Peptide Nucleic AcidsNucleic Acid ChemistryPeptide EngineeringSynthetic BiologyMolecular Biology +1

Preclinical Characteristics of the Hepatitis C Virus NS3/4A Protease Inhibitor ITMN-191 (R7227)

Scott D. Seiwert, Steven W. Andrews, Yutong Jiang, +21

Antimicrobial Agents and Chemotherapy

BiochemistryViral HepatitisMedicineNatural SciencesImmunology +12

Discovery of Danoprevir (ITMN-191/R7227), a Highly Selective and Potent Inhibitor of Hepatitis C Virus (HCV) NS3/4A Protease

Yutong Jiang, Steven W. Andrews, Kevin R. Condroski, +20

Journal of Medicinal Chemistry

Hepatitis C VirusImmunologyAntiviral DrugViral Structural ProteinHcv Ns3 Protease +15

Design and Activity of Specific Hypoxia-Inducible Factor-2α (HIF-2α) Inhibitors for the Treatment of Clear Cell Renal Cell Carcinoma: Discovery of Clinical Candidate (<i>S</i>)-3-((2,2-Difluoro-1-hydroxy-7-(methylsulfonyl)-2,3-dihydro-1<i>H</i>-inden-4-yl)oxy)-5-fluorobenzonitrile (PT2385)

Paul M. Wehn, James P. Rizzi, Darryl D. Dixon, +22

Journal of Medicinal Chemistry