Abhishek A. Chakraborty

On-target efficacy of a HIF-2α antagonist in preclinical kidney cancer models

Hyejin Cho, Xinlin Du, James P. Rizzi et al. · Nature · 2016 · 441 citations · Full text

Urology, Oncology, Hif-2α Antagonist +7

Histone demethylase KDM6A directly senses oxygen to control chromatin and cell fate

Abhishek A. Chakraborty, Tuomas Laukka, Matti Myllykoski et al. · Science · 2019 · 405 citations · Full text

Transaminase Inhibition by 2-Hydroxyglutarate Impairs Glutamate Biosynthesis and Redox Homeostasis in Glioma

Samuel K. McBrayer, Jared R. Mayers, Gabriel J. DiNatale et al. · Cell · 2018 · 350 citations · Full text

Biochemistry, Medicine, Lipid Peroxidation +9

pVHL suppresses kinase activity of Akt in a proline-hydroxylation–dependent manner

Jianping Guo, Abhishek A. Chakraborty, Pengda Liu et al. · Science · 2016 · 207 citations

Akt Activity, Cancer Biology, Cellular Physiology +25

GAP43-dependent mitochondria transfer from astrocytes enhances glioblastoma tumorigenicity

Dionysios C. Watson, Simon Storevik, Shannon Sherwin Moreino et al. · Nature Cancer · 2023 · 183 citations · Full text

Intact Mitochondria, Neuro-oncology, Gap43-dependent Mitochondria +11