Inhibition of HIF-1α enhances anti-tumor effects of dendritic cell-based vaccination in a mouse model of breast cancer

Adenosine generation catalyzed by CD39 and CD73 expressed on regulatory T cells mediates immune suppression

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Life Sciences, Immunology, Molecular Biology +15

PD-L1 is a novel direct target of HIF-1α, and its blockade under hypoxia enhanced MDSC-mediated T cell activation

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HIF1α–dependent glycolytic pathway orchestrates a metabolic checkpoint for the differentiation of TH17 and Treg cells

Lewis Z. Shi, Ruoning Wang, Gonghua Huang et al. · The Journal of Experimental Medicine · 2011 · 1.8K citations · Full text

Life Sciences, Cell Biology, Immunology +17

Tumour hypoxia promotes tolerance and angiogenesis via CCL28 and Treg cells

Andrea Facciabene, Xiaohui Peng, Ian S. Hagemann et al. · Nature · 2011 · 1.4K citations

Medicine, Cancer Biology, Oncology +14

GM-CSF Mouse Bone Marrow Cultures Comprise a Heterogeneous Population of CD11c+MHCII+ Macrophages and Dendritic Cells

Julie Helft, Jan P. Böttcher, Probir Chakravarty et al. · Immunity · 2015 · 811 citations · Full text

Life Sciences, Cell Biology, Immunology +12