Structure, activity and uptake mechanism of siRNA-lipid nanoparticles with an asymmetric ionizable lipid

Duplexes of 21-nucleotide RNAs mediate RNA interference in cultured mammalian cells

Sayda M. Elbashir, Jens Harborth, Winfried Lendeckel et al. · Nature · 2001 · 9.4K citations

Life Sciences, Molecular Biology, Molecular Genetics +7

Rational design of cationic lipids for siRNA delivery

Sean C. Semple, Akin Akinc, Jianxin Chen et al. · Nature Biotechnology · 2010 · 1.8K citations

Pharmacy, Molecular Pharmaceutics, Pharmaceutics +16

Image-based analysis of lipid nanoparticle–mediated siRNA delivery, intracellular trafficking and endosomal escape

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Pharmacy, Molecular Pharmaceutics, Pharmaceutics +17

Maximizing the Potency of siRNA Lipid Nanoparticles for Hepatic Gene Silencing In Vivo**

Muthusamy Jayaraman, Steven M. Ansell, Barbara L. Mui et al. · Angewandte Chemie International Edition · 2012 · 1.2K citations · Full text

Pharmacy, Pharmaceutics, Pharmacology +17

A combinatorial library of lipid-like materials for delivery of RNAi therapeutics

Akin Akinc, Andreas Zumbuehl, Michael S. Goldberg et al. · Nature Biotechnology · 2008 · 1.2K citations

Pharmacy, Molecular Biology, Molecular Pharmaceutics +16