Hydrophobic CDR3 residues promote the development of self-reactive T cells

An αβ T Cell Receptor Structure at 2.5 Å and Its Orientation in the TCR-MHC Complex

K. Christopher García, Massimo Degano, Robyn L. Stanfield et al. · Science · 1996 · 1.3K citations

Signal Transduction, Tcr-mhc Complex, Peptide Library +15

T cell receptor signal strength in Treg and iNKT cell development demonstrated by a novel fluorescent reporter mouse

Amy E. Moran, Keli L. Holzapfel, Yan Xing et al. · The Journal of Experimental Medicine · 2011 · 1K citations · Full text

Lymphocyte Development, T-regulatory Cell, Immunology +19

BH3-only Bcl-2 family member Bim is required for apoptosis of autoreactive thymocytes

Philippe Bouillet, Jared F. Purton, Dale I. Godfrey et al. · Nature · 2002 · 764 citations

Hematological Malignancy, Autoimmune Disease, Lymphocyte Development +9

Continuous requirement for the TCR in regulatory T cell function

Andrew G. Levine, Aaron Arvey, Wei Jin et al. · Nature Immunology · 2014 · 503 citations · Full text

Signal Transduction, T-regulatory Cell, Immunology +8

The MHC Reactivity of the T Cell Repertoire Prior to Positive and Negative Selection

Jens Zerrahn, Werner Held, David H. Raulet · Cell · 1997 · 319 citations · Full text

Autoimmune Disease, Adaptive Immune System, T-regulatory Cell +13