Inflammasome priming increases retinal pigment epithelial cell susceptibility to lipofuscin phototoxicity by changing the cell death mechanism from apoptosis to pyroptosis

Global data on visual impairment in the year 2002.

Serge Resnikoff, Donatella Pascolini, Daniel Etya’ale et al. · PubMed · 2004 · 4.2K citations

Medicine, Ophthalmology, Global Health +16

A small-molecule inhibitor of the NLRP3 inflammasome for the treatment of inflammatory diseases

Rebecca C. Coll, Avril A. B. Robertson, Jae Jin Chae et al. · Nature Medicine · 2015 · 2.8K citations · Full text

Life Sciences, Immunology, Medicinal Chemistry +15

Age-related changes in oxidized proteins.

Cynthia N. Oliver, Byungchan Ahn, Elena J. Moerman et al. · Journal of Biological Chemistry · 1987 · 1.3K citations · Full text

Life Sciences, Biochemistry, Physiology +17

DICER1 Loss and Alu RNA Induce Age-Related Macular Degeneration via the NLRP3 Inflammasome and MyD88

Valeria Tarallo, Yoshio Hirano, Bradley D. Gelfand et al. · Cell · 2012 · 594 citations · Full text

Medicine, Molecular Biology, Ophthalmology +12

Blue Light-induced Reactivity of Retinal Age Pigment

Małgorzata Różanowska, John Jarvis-Evans, Witold Korytowski et al. · Journal of Biological Chemistry · 1995 · 431 citations · Full text

Life Sciences, Ophthalmology, Vision Science +17