Concepedia

β-Amino acid-containing hybrid peptides—new opportunities in peptidomimetics

Marie‐Isabel Aguilar, Anthony W. Purcell, Romila Devi, Rebecca A. Lew, Jamie Rossjohn, A. Ian Smith, Patrick Perlmutter

Organic & Biomolecular Chemistry · 2007 · 128 citations · 16 references

DOI

Concepts

Abstract

Hybrid peptides consisting of alpha-amino acids with judiciously placed beta-amino acids show great promise as peptidomimetics in an increasing range of therapeutic applications. This reflects a combination of increased stability, high specificity and relative ease of synthesis.

References

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