Bernárd P. Roques

Unresponsiveness to Cannabinoids and Reduced Addictive Effects of Opiates in CB ₁ Receptor Knockout Mice

Catherine Ledent, Olga Valverde, G Cossu et al. · Science · 1999 · 3.6K citations

Medicine, Neuroscience, Pharmacology +15

Loss of morphine-induced analgesia, reward effect and withdrawal symptoms in mice lacking the µ-opioid-receptor gene

Hans W. D. Matthes, Rafaël Maldonado, Frédéric Simonin et al. · Nature · 1996 · 1.7K citations

Medicine, Neuroscience, Pharmacology +17

The HIV-1 Viral Protein R Induces Apoptosis via a Direct Effect on the Mitochondrial Permeability Transition Pore

Étienne Jacotot, L Ravagnan, Markus Loeffler et al. · The Journal of Experimental Medicine · 2000 · 447 citations · Full text

Life Sciences, Biochemistry, Molecular Biology +17

Absence of opiate rewarding effects in mice lacking dopamine D2 receptors

Adolfo Saiardi, Olga Valverde, Tarek A. Samad et al. · Nature · 1997 · 440 citations

Medicine, Neurobiology, Neuroscience +14

Disruption of the κ‐opioid receptor gene in mice enhances sensitivity to chemical visceral pain, impairs pharmacological actions of the selective κ‐agonist U‐50,488H and attenuates morphine withdrawal

Frédéric Simonin, Olga Valverde, Claire Smadja et al. · The EMBO Journal · 1998 · 413 citations

Medicine, Pharmacology, Molecular Pharmacology +16