Loss of morphine-induced analgesia, reward effect and withdrawal symptoms in mice lacking the µ-opioid-receptor gene

Disruption of the Hox-1.6 homeobox gene results in defects in a region corresponding to its rostral domain of expression

Thomas Lufkin, Andrée Dierich, Marianne LeMeur et al. · Cell · 1991 · 699 citations

Life Sciences, Genetics, Molecular Genetics +10

A general role for adaptations in G-proteins and the cyclic AMP system in mediating the chronic actions of morphine and cocaine on neuronal function

Rose Z. Terwilliger, Dana Beitner‐Johnson, Kevin A. Sevarino et al. · Brain Research · 1991 · 540 citations · Full text

Life Sciences, Neuroscience, Pharmacology +17

Multiple opioid receptors: ligand selectivity profiles and binding site signatures.

A Goldstein, A Naidu · Molecular Pharmacology · 1989 · 447 citations

Medicine, Medicinal Chemistry, Pharmacology +17

Reduction of Morphine Abstinence in Mice with a Mutation in the Gene Encoding CREB

Rafaël Maldonado, Julie A. Blendy, Eleni T. Tzavara et al. · Science · 1996 · 296 citations

Medicine, Neurobiology, Pharmacology +17

The mouse Pgk-1 gene promoter contains an upstream activator sequence

Michael W. McBurney, Leslie C. Sutherland, Chakar N. Adra et al. · Nucleic Acids Research · 1991 · 200 citations · Full text

Life Sciences, Genetics, Molecular Biology +17