Frédéric Simonin

Loss of morphine-induced analgesia, reward effect and withdrawal symptoms in mice lacking the µ-opioid-receptor gene

Hans W. D. Matthes, Rafaël Maldonado, Frédéric Simonin et al. · Nature · 1996 · 1.7K citations

Molecular Pharmacology, µ-Opioid-receptor Gene, Pain Disorders +15

Mice deficient for δ- and μ-opioid receptors exhibit opposing alterations of emotional responses

Dominique Filliol, Sandy Ghozland, Johanna Chluba et al. · Nature Genetics · 2000 · 664 citations

Health Sciences, Behavioral Neuroscience, Addiction +12

Disruption of the kappa -opioid receptor gene in mice enhances sensitivity to chemical visceral pain, impairs pharmacological actions of the selective kappa -agonist U-50,488H and attenuates morphine withdrawal

Frédéric Simonin · The EMBO Journal · 1998 · 413 citations

Inflammation, Chemical Visceral Pain, Health Sciences +12

The second zinc-finger domain of poly(ADP-ribose) polymerase determines specificity for single-stranded breaks in DNA.

Gérard Gradwohl, Josiane Ménissier-de Murcia, M. Molinete et al. · Proceedings of the National Academy of Sciences · 1990 · 277 citations · Full text

Putative Zinc Fingers, Genetics, Dna Analysis +18

Motivational Effects of Cannabinoids Are Mediated by μ-Opioid and κ-Opioid Receptors

Sandy Ghozland, Hans W. D. Matthes, Frédéric Simonin et al. · Journal of Neuroscience · 2002 · 257 citations · Full text

Substance Use, Cannabinoid Pharmacology, Psychology +24