Frédéric Simonin

Loss of morphine-induced analgesia, reward effect and withdrawal symptoms in mice lacking the µ-opioid-receptor gene

Hans W. D. Matthes, Rafaël Maldonado, Frédéric Simonin et al. · Nature · 1996 · 1.7K citations

Medicine, Neuroscience, Pharmacology +17

Mice deficient for δ- and μ-opioid receptors exhibit opposing alterations of emotional responses

Dominique Filliol, Sandy Ghozland, Johanna Chluba et al. · Nature Genetics · 2000 · 668 citations

Life Sciences, Neurobiology, Neuroscience +13

Disruption of the κ‐opioid receptor gene in mice enhances sensitivity to chemical visceral pain, impairs pharmacological actions of the selective κ‐agonist U‐50,488H and attenuates morphine withdrawal

Frédéric Simonin, Olga Valverde, Claire Smadja et al. · The EMBO Journal · 1998 · 413 citations

Medicine, Pharmacology, Molecular Pharmacology +16

The second zinc-finger domain of poly(ADP-ribose) polymerase determines specificity for single-stranded breaks in DNA.

Gérard Gradwohl, Josiane Ménissier-de Murcia, M. Molinete et al. · Proceedings of the National Academy of Sciences · 1990 · 278 citations · Full text

Life Sciences, Biochemistry, Molecular Biology +15

Motivational Effects of Cannabinoids Are Mediated by μ-Opioid and κ-Opioid Receptors

Sandy Ghozland, Hans W. D. Matthes, Frédéric Simonin et al. · Journal of Neuroscience · 2002 · 259 citations · Full text

Medicine, Neuroscience, Pharmacology +17