Absence of opiate rewarding effects in mice lacking dopamine D2 receptors

Drugs abused by humans preferentially increase synaptic dopamine concentrations in the mesolimbic system of freely moving rats.

G. Di Chiara, Assunta Impérato · Proceedings of the National Academy of Sciences · 1988 · 4.7K citations · Full text

Psychopharmacology, Pharmacotherapy, Synaptic Dopamine Concentrations +18

A psychomotor stimulant theory of addiction.

Roy A. Wise, Michael A. Bozarth · Psychological Review · 1987 · 2.7K citations

Neuropsychology, Substance Use, Behavioral Addiction +21

Loss of morphine-induced analgesia, reward effect and withdrawal symptoms in mice lacking the µ-opioid-receptor gene

Hans W. D. Matthes, Rafaël Maldonado, Frédéric Simonin et al. · Nature · 1996 · 1.7K citations

Molecular Pharmacology, µ-Opioid-receptor Gene, Pain Disorders +15

Destruction of dopamine in the nucleus accumbens selectively attenuates cocaine but not heroin self-administration in rats

Hugh O. Pettit, Aaron Ettenberg, Floyd E. Bloom et al. · Psychopharmacology · 1984 · 652 citations

Substance Abuse, Psychoactive Drug, Substance Use +11

Parkinsonian-like locomotor impairment in mice lacking dopamine D2 receptors

Ja‐Hyun Baik, Roberto Picetti, Adolfo Saiardi et al. · Nature · 1995 · 648 citations

Parkinson Disease, Neuropharmacology, Neuroscience +3