Journal of Agricultural and Food Chemistry · 2011 · 576 citations · 23 references
PharmacyMaterials SciencePharmaceuticsDrug DeliveryNanomaterialsPharmaceutical FormulationDrug EncapsulationNanomaterials For Drug DeliveryNanoparticle CharacterizationNanoparticle Delivery SystemsNanoparticle FormulationsOral NanocarriersChitosanControlled ReleaseControlled Release MaterialsEncapsulationEncapsulation EfficiencyNutraceutical EncapsulationPhysicochemical PropertiesVitamin Encapsulation
The study aimed to develop zein nanoparticles coated with carboxymethyl chitosan for encapsulating vitamin D3. VD3 was encapsulated into zein nanoparticles by low‑energy phase separation, simultaneously coated with CMCS, cross‑linked with calcium to form thicker, denser layers, and the resulting particles were characterized by DSC and FTIR. The CMCS‑coated nanoparticles were spherical (86–200 nm), achieved an encapsulation efficiency of 87.9% versus 52.2% for uncoated zein, and exhibited improved controlled release in PBS and simulated gastrointestinal media, enhanced UV photostability, and overall superior chemical stability for hydrophobic nutrients.
In this study, zein nanoparticles coated with carboxymethyl chitosan (CMCS) were prepared to encapsulate vitamin D3 (VD3). VD3 was first encapsulated into zein nanoparticles using a low-energy phase separation method and coated with CMCS simultaneously. Then, calcium was added to cross-link CMCS to achieve thicker and denser coatings. The nanoparticles with CMCS coatings had a spherical structure with particle size from 86 to 200 nm. The encapsulation efficiency was greatly improved to 87.9% after CMCS coating, compared with 52.2% for that using zein as a single encapsulant. The physicochemical properties were characterized by differential scanning calorimetry and Fourier transform infrared spectroscopy. Nanoparticles with coatings provided better controlled release of VD3 in both PBS medium and simulated gastrointestinal tract. Photostability against UV light was significantly improved after encapsulation. Encapsulation of hydrophobic nutrients in zein nanoparticles with CMCS coatings is a promising approach to enhance chemical stability and controlled release property.
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Casein micelle as a natural nano-capsular vehicle for nutraceuticals
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