Novel p53 mutants selected in BRCA-associated tumours which dissociate transformation suppression from other wild-type p53 functions

A Strong Candidate for the Breast and Ovarian Cancer Susceptibility Gene <i>BRCA1</i>

Yoshio Miki, Jeffrey Swensen, Donna Shattuck-Eidens et al. · Science · 1994 · 6.1K citations

Breast Oncology, Engineering, Genetics +16

Mdm2 promotes the rapid degradation of p53

Ygal Haupt, Ruth Maya, Anat Kazaz et al. · Nature · 1997 · 4.5K citations

Tumor Biology, Medicine, Rapid Degradation +6

Tumor suppressor p53 is a direct transcriptional activator of the human bax gene

Toshiyuki Miyashita, John C. Reed · Cell · 1995 · 4.1K citations · Full text

Tumor Biology, Oncogenic Agent, Medicine +10

Identification of the breast cancer susceptibility gene BRCA2

Richard Wooster, Graham R. Bignell, Jonathan Lancaster et al. · Nature · 1995 · 3.6K citations

Breast Oncology, Cancer Genomics, Breast Cancer +3

Regulation of p53 stability by Mdm2

Michael H.G. Kubbutat, Stephen N. Jones, Karen H. Vousden · Nature · 1997 · 3.3K citations

Tumor Biology, Tumor Suppressor, Medicine +3