Publication | Open Access
Cathepsin C Inhibitors: Property Optimization and Identification of a Clinical Candidate
54
Citations
14
References
2014
Year
Drug TargetCathepsin C InhibitorsLead IdentificationClinical CandidatePharmacotherapyChemical BiologyMedicinal ChemistryBioanalysisProperty OptimizationBiochemistryDrug DevelopmentPharmacologySar UnderstandingNatural SciencesRational Drug DesignOptimization ProgramMedicineLead GenerationDrug DiscoveryPharmaceutical Research
A lead generation and optimization program delivered the highly selective and potent CatC inhibitor 10 as an in vivo tool compound and potential development candidate. Structural studies were undertaken to generate SAR understanding.
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