Oncogene · 2001 · 132 citations · 23 references
Life SciencesGeneticsMolecular GeneticsApoptosisDna RepairMolecular OncologyDna DamageDna Damage SignalingDna Damage-induced ApoptosisGene Knock-in StrategiesGenotoxic CarcinogenesisDna Damage-induced Cell DeathP53 InactivationP53 MutationP53 Protein ResponseP53-mediated ApoptosisTp53 Mutations
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Mice deficient for p53 are developmentally normal but susceptible to spontaneous tumours
Lawrence A. Donehower, Michele Harvey, Betty L. Slagle et al. · Nature · 1992 · 4.7K citations
p53 is required for radiation-induced apoptosis in mouse thymocytes
Scott W. Lowe, Earlene M. Schmitt, Sallie W. Smith et al. · Nature · 1993 · 2.9K citations
Medicine, Cell Biology, Oncology +14
Crystal Structure of a p53 Tumor Suppressor-DNA Complex: Understanding Tumorigenic Mutations
Yunje Cho, Svetlana S. Gorina, Philip D. Jeffrey et al. · Science · 1994 · 2.5K citations
Thymocyte apoptosis induced by p53-dependent and independent pathways
Alan R. Clarke, Colin A. Purdie, David J. Harrison et al. · Nature · 1993 · 2.3K citations
Tumor spectrum analysis in p53-mutant mice
Tyler Jacks, Lee Ann Remington, Bart O. Williams et al. · Current Biology · 1994 · 2.1K citations
Medicine, Cancer Biology, Oncology +12