IKKβ Couples Hepatocyte Death to Cytokine-Driven Compensatory Proliferation that Promotes Chemical Hepatocarcinogenesis

Shin Maeda, Hideaki Kamata, Jun‐Li Luo, +2

Cell

InflammationSignal TransductionHepatologySignaling PathwayLiver Physiology +11

Carcinoma-produced factors activate myeloid cells through TLR2 to stimulate metastasis

Sun-Hwa Kim, Hiroyuki Takahashi, Wan‐Wan Lin, +5

Nature

OncologyMedicineImmunologyMyelopoiesisCarcinoma-produced Factors +6

B-cell-derived lymphotoxin promotes castration-resistant prostate cancer

Massimo Ammirante, Jun‐Li Luo, Sergei I. Grivennikov, +2

Nature

UrologyMedicineCastration-resistant Prostate CancerProstatic DiseaseCancer Biology

Inhibition of NF-κB in cancer cells converts inflammation- induced tumor growth mediated by TNFα to TRAIL-mediated tumor regression

Jun‐Li Luo, Shin Maeda, Li‐Chung Hsu, +2

Cancer Cell

InflammationCancer ImmunosurveillanceTrail-mediated Tumor RegressionMedicineImmunology +8

Nuclear cytokine-activated IKKα controls prostate cancer metastasis by repressing Maspin

Jun‐Li Luo, Wei Phin Tan, Jill M. Ricono, +5

Nature

Transcriptional RegulationUrologySignaling PathwayMedicineProstatic Disease +5

The protein kinase PKR is required for macrophage apoptosis after activation of Toll-like receptor 4

Li‐Chung Hsu, Jin Mo Park, Kezhong Zhang, +6

Nature

InflammationToll-like ReceptorsProtein Kinase PkrSignal TransductionAutoimmune Disease +12

IKKβ Is Required for Prevention of Apoptosis Mediated by Cell-Bound but Not by Circulating TNFα

Shin Maeda, Lufen Chang, Zhiwei Li, +3

Immunity

InflammationCytokineSignal TransductionSignaling PathwayMedicine +10

Essential Cytoplasmic Translocation of a Cytokine Receptor–Assembled Signaling Complex

Atsushi Matsuzawa, Ping‐Hui Tseng, Sivakumar Vallabhapurapu, +6

Science

ApoptosisImmunologyCell DeathImmunologic MechanismInnate Immunity +19

IκB kinase α kinase activity is required for self-renewal of ErbB2/Her2-transformed mammary tumor-initiating cells

Yixue Cao, Jun‐Li Luo, Michael Karin

Proceedings of the National Academy of Sciences

Breast OncologyCell ProliferationCancer BiologyMammary Gland DevelopmentTumor Biology +16

IL6-Mediated Suppression of miR-200c Directs Constitutive Activation of Inflammatory Signaling Circuit Driving Transformation and Tumorigenesis

Matjaž Rokavec, Weilin Wu, Jun‐Li Luo

Molecular Cell

InflammationCytokineImmunologyChronic InflammationImmunologic Mechanism +7