GigaScience · 2016 · 28 citations · 14 references
Natural SciencesEcologySystems BiologyEcosystem ManagementEnvironmental ModelingSustainability ScienceEcological ModelingEcological System ModelingEcological SystemsEnvironmental Systems ModelingSocial-ecological SystemsSocio-ecological SystemsEcosystem SimulationHuman-environment SystemsIsland EcologySocial-ecological InteractionsSocial-ecological ResilienceSystem Model DevelopmentSystems EcologyVirtual Ecosystems
Systems biology promises to revolutionize medicine, yet human wellbeing is also inherently linked to healthy societies and environments (sustainability). The IDEA Consortium is a systems ecology open science initiative to conduct the basic scientific research needed to build use-oriented simulations (avatars) of entire social-ecological systems. Islands are the most scientifically tractable places for these studies and we begin with one of the best known: Moorea, French Polynesia. The Moorea IDEA will be a sustainability simulator modeling links and feedbacks between climate, environment, biodiversity, and human activities across a coupled marine-terrestrial landscape. As a model system, the resulting knowledge and tools will improve our ability to predict human and natural change on Moorea and elsewhere at scales relevant to management/conservation actions.
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A Whole-Cell Computational Model Predicts Phenotype from Genotype
Jonathan R. Karr, Jayodita C. Sanghvi, Derek N. Macklin et al. · Cell · 2012 · 1.3K citations
Systems Biology and New Technologies Enable Predictive and Preventative Medicine
Leroy Hood, James R. Heath, Michael E. Phelps et al. · Science · 2004 · 1.1K citations
William C. Clark, Thomas P. Tomich, Meine van Noordwijk et al. · Proceedings of the National Academy of Sciences · 2011 · 523 citations · Full text