Derek N. Macklin

A Whole-Cell Computational Model Predicts Phenotype from Genotype

Jonathan R. Karr, Jayodita C. Sanghvi, Derek N. Macklin et al. · Cell · 2012 · 1.3K citations

Allelic Variant, Genotype-phenotype Association, Genetics +5

Deep Learning Automates the Quantitative Analysis of Individual Cells in Live-Cell Imaging Experiments

David Ashley Van Valen, Takamasa Kudo, Keara Lane et al. · PLoS Computational Biology · 2016 · 634 citations · Full text

Convolutional Neural Network, Engineering, Microscopy +23

Measuring Signaling and RNA-Seq in the Same Cell Links Gene Expression to Dynamic Patterns of NF-κB Activation

Keara Lane, David Van Valen, Mialy DeFelice et al. · Cell Systems · 2017 · 159 citations · Full text

Dynamic Patterns, Environmental Signaling, Transcriptional Regulation +15

Simultaneous cross-evaluation of heterogeneous <i>E. coli</i> datasets via mechanistic simulation

Derek N. Macklin, Travis A. Ahn-Horst, Heejo Choi et al. · Science · 2020 · 155 citations · Full text

Live-cell measurements of kinase activity in single cells using translocation reporters

Takamasa Kudo, Stevan Jeknić, Derek N. Macklin et al. · Nature Protocols · 2017 · 119 citations

Live-cell Measurements, Signal Transduction, Medicine +8