Antibacterial and antioxidant activities of Streptomyces species SRDP-H03 isolated from soil of Hosudi, Karnataka, India

Abstract

In the present study, we report antibacterial and antioxidant activity of ethyl acetate extract of Streptomyces species SRDP-H03 isolated from rhizosphere soil of Hosudi, Karnataka, India. The isolate SRDP-H03 was assigned to the genus Streptomyces based on the cultural and microscopic characteristics. The ethyl acetate extract of the isolate SRDP-H03 showed marked inhibition of Gram positive bacteria than Gram negative bacteria. The extract was found to possess dose dependent DPPH free radical scavenging and Ferric reducing activity. UV spectral data of ethyl acetate extract showed strong absorption maxima (λmax) at 267 and 340nm. The isolate can be a potential candidate for the development of novel therapeutic agents active against pathogens and free radicals. Further studies on genomic characterization of isolate and isolation and structure determination of the bioactive compounds are under progress.