Protocatechualdehyde Protects Against Cerebral Ischemia-Reperfusion-Induced Oxidative Injury Via Protein Kinase Cε/Nrf2/HO-1 Pathway

Reversible middle cerebral artery occlusion without craniectomy in rats.

Enrique Zea Longa, Philip R. Weinstein, Shaun W. Carlson et al. · Stroke · 1989 · 7.5K citations · Full text

Medicine, Neuroscience, Surgery +17

Transcription Factor Nrf2 Coordinately Regulates a Group of Oxidative Stress-inducible Genes in Macrophages

Tetsuro Ishii, Ken Itoh, Satoru Takahashi et al. · Journal of Biological Chemistry · 2000 · 1.5K citations · Full text

Life Sciences, Biochemistry, Cell Biology +17

Identification of Nrf2-regulated genes induced by the chemopreventive agent sulforaphane by oligonucleotide microarray.

Rajesh K. Thimmulappa, Kim H., Sorachai Srisuma et al. · PubMed · 2002 · 1.2K citations

Life Sciences, Molecular Biology, Toxicology +17

Sensitivity to carcinogenesis is increased and chemoprotective efficacy of enzyme inducers is lost in <i>nrf2</i> transcription factor-deficient mice

Minerva Ramos‐Gómez, Mi-Kyoung Kwak, Patrick M. Dolan et al. · Proceedings of the National Academy of Sciences · 2001 · 1.1K citations · Full text

Life Sciences, Molecular Biology, Oncology +17

Keap1-null mutation leads to postnatal lethality due to constitutive Nrf2 activation

Nobunao Wakabayashi, Ken Itoh, Junko Wakabayashi et al. · Nature Genetics · 2003 · 888 citations

Life Sciences, Genetics, Molecular Biology +11