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A step forward to improve recombinant protein production in Pichia pastoris: From specific growth rate effect on protein secretion to carbon-starving conditions as advanced strategy

Xavier Garcia‐Ortega, Núria Adelantado, Pau Ferrer, José Luis González Montesinos, Francisco Valero

Process Biochemistry · 2016 · 46 citations · 47 references

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47

Glucose Depletion Rapidly Inhibits Translation Initiation in Yeast

Mark Ashe, Susan K. De Long, Alan B. Sachs · Molecular Biology of the Cell · 2000 · 457 citations

, , +16

Protein folding and conformational stress in microbial cells producing recombinant proteins: a host comparative overview

Brigitte Gasser, Markku Saloheimo, Ursula Rinas et al. · Microbial Cell Factories · 2008 · 331 citations · Full text

, , +15

Development trends for therapeutic antibody fragments

Aaron Nelson, Janice M. Reichert · Nature Biotechnology · 2009 · 305 citations

, , +14

Effects of gene dosage, promoters, and substrates on unfolded protein stress of recombinant <i>Pichia pastoris</i>

Hubertus Hohenblum, Brigitte Gasser, Michael Maurer et al. · Biotechnology and Bioengineering · 2003 · 279 citations

, , +14

Promoter sequences direct cytoplasmic localization and translation of mRNAs during starvation in yeast

Brian M. Zid, Erin K. O’Shea · Nature · 2014 · 241 citations

, , +12