A case series of re-establishment of neuromuscular block with rocuronium after sugammadex reversal

A Novel Concept of Reversing Neuromuscular Block: Chemical Encapsulation of Rocuronium Bromide by a Cyclodextrin-Based Synthetic Host The discovery of Org 25969 is the result of teamwork with contributions from a number of scientists both inside Organon and outside the company. We would like in particular to acknowledge the following scientists for their invaluable contributions: E. Hutchinson, D. Stevenson, R. Roy, and J. Pick for scaling-up the synthesis; F. Hope, S. Miller, and R. Mason for various in vitro and in vivo pharmacological testing; R. Watson, B. Montgomery, P. Desmond, and A. Osprey for all their analytical effort; and R. McGuire and J. Mestres for graphical presentation of the X-ray crystal structure of the Org 25969–rocuronium complex (Figure 3). We would also like to thank Prof. A. Cooper of Glasgow University who has critically reproduced our calorimetry data of Org 25969–rocuronium complexation (Figure 2).

A. Bom, Mark Philip Bradley, Ken Cameron et al. · Angewandte Chemie International Edition · 2002 · 457 citations

Pharmacy, Medicinal Chemistry, Pharmacology +15

First Human Exposure of Org 25969, a Novel Agent to Reverse the Action of Rocuronium Bromide

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A Novel Concept of Reversing Neuromuscular Block: Chemical Encapsulation of Rocuronium Bromide by a Cyclodextrin-Based Synthetic Host

A. Bom, Mark Philip Bradley, Ken Cameron et al. · Angewandte Chemie · 2002 · 226 citations

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Reversal with Sugammadex in the Absence of Monitoring Did Not Preclude Residual Neuromuscular Block

Yoshifumi Kotake, Ryoichi Ochiai, Takahiro Suzuki et al. · Anesthesia & Analgesia · 2013 · 207 citations

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Reversal of Rocuronium-induced Neuromuscular Blockade with Sugammadex in Pediatric and Adult Surgical Patients

Benoît Plaud, Olli A. Meretoja, R. Hofmockel et al. · Anesthesiology · 2009 · 204 citations · Full text

Medicine, Pharmacology, Pharmacotherapy +13