Reversal Agents

Reversal Agent is a pharmacological substance that belongs to the class of perioperative drugs designed to specifically counteract the effects of anesthetic or neuromuscular blocking agents, thereby restoring physiological function through targeted antagonism.

256

Publications

15.8K

Citations

1.2K

Authors

468

Institutions

Publications per year

2017–2026

Parents

Perioperative Pharmacology

Children

Anesthetic ReversalCholinergic ReversalGlycopyrrolate Combination TherapyNondepolarizing Neuromuscular Blocker AntagonismOpioid AntagonistsPerioperative Drug AntagonismProtamine SulfateReversal Agent DosingReversal Agent PharmacodynamicsReversal Agent Pharmacokinetics

Publications

256

Idarucizumab for Dabigatran Reversal

Charles V. Pollack, Paul A. Reilly, John W. Eikelboom et al. · New England Journal of Medicine · 2015 · 1.5K citations

Medicine, Pharmacology, Pharmacotherapy +4

Idarucizumab for dabigatran reversal

Anna D. Garrett, Bcps · 2015 · 1.2K citations

Medicine, Pharmacology, Pharmacotherapy +4

Reversal of late septic shock with supraphysiologic doses of hydrocortisone

Pierre‐Édouard Bollaert, Claire Charpentier, Bruno Lévy et al. · Critical Care Medicine · 1998 · 880 citations

Medicine, Pharmacology, Pharmacotherapy +15

A Novel Concept of Reversing Neuromuscular Block: Chemical Encapsulation of Rocuronium Bromide by a Cyclodextrin-Based Synthetic Host The discovery of Org 25969 is the result of teamwork with contributions from a number of scientists both inside Organon and outside the company. We would like in particular to acknowledge the following scientists for their invaluable contributions: E. Hutchinson, D. Stevenson, R. Roy, and J. Pick for scaling-up the synthesis; F. Hope, S. Miller, and R. Mason for various in vitro and in vivo pharmacological testing; R. Watson, B. Montgomery, P. Desmond, and A. Osprey for all their analytical effort; and R. McGuire and J. Mestres for graphical presentation of the X-ray crystal structure of the Org 25969–rocuronium complex (Figure 3). We would also like to thank Prof. A. Cooper of Glasgow University who has critically reproduced our calorimetry data of Org 25969–rocuronium complexation (Figure 2).

A. Bom, Mark Philip Bradley, Ken Cameron et al. · Angewandte Chemie International Edition · 2002 · 457 citations

Pharmacy, Medicinal Chemistry, Pharmacology +15

Reversal of Profound Rocuronium-induced Blockade with Sugammadex

R Kevin Jones, James E. Caldwell, Sorin J. Brull et al. · Anesthesiology · 2008 · 374 citations · Full text

Medicine, Anesthesiology, Surgery +16

1–5 of 256

Authors

1.2K

AB
A. Bom
Erasmus University Rotterdam, Netherlands
9 publications · 1.1K citations
9
h-index
LB
L.H.D.J. Booij
Radboud University Nijmegen, Netherlands
5 publications · 311 citations
5
h-index
JV
J. van Egmond
Radboud University Nijmegen, Netherlands
5 publications · 714 citations
5
h-index
ET
E. Tassonyi
University Hospital of Geneva, Switzerland
4 publications · 191 citations
4
h-index
ME
Matthias Eikermann
Harvard University, United States
4 publications · 369 citations
4
h-index

1–5 of 1.2K

Institutions

468

1–8 of 468

Venues

Anesthesiology
21 publications · 2.5K citations
18
h-index
Anesthesia & Analgesia
22 publications · 1.2K citations
17
h-index
PubMed
Repository · 13 publications · 283 citations
12
h-index
British Journal of Anaesthesia
12 publications · 620 citations
11
h-index
European Journal of Anaesthesiology
EJA · 11 publications · 433 citations
10
h-index

1–5