The novel selective PPARα modulator (SPPARMα) pemafibrate improves dyslipidemia, enhances reverse cholesterol transport and decreases inflammation and atherosclerosis

HDL Cholesterol Efflux Capacity and Incident Cardiovascular Events

Anand Rohatgi, Amit Khera, Jarett D. Berry et al. · New England Journal of Medicine · 2014 · 1.4K citations · Full text

Medicine, Cardiology, Clinical Epidemiology +16

PPARalpha and PPARgamma activators direct a distinct tissue‐specific transcriptional response via a PPRE in the lipoprotein lipase gene.

Kristina Schoonjans, Julia Peinado‐Onsurbe, Anne‐Marie Lefebvre et al. · The EMBO Journal · 1996 · 1.2K citations · Full text

Life Sciences, Biochemistry, Molecular Biology +16

PPAR-α and PPAR-γ activators induce cholesterol removal from human macrophage foam cells through stimulation of the ABCA1 pathway

Giulia Chinetti, Sophie Lestavel, Virginie Bocher et al. · Nature Medicine · 2001 · 1.2K citations

Life Sciences, Biochemistry, Pharmacology +17

Activation of human aortic smooth-muscle cells is inhibited by PPARα but not by PPARγ activators

Bart Staels, Wolfgang Köenig, Régine Merval et al. · Nature · 1998 · 1.1K citations

Life Sciences, Molecular Biology, Pharmacology +14

Peroxisome Proliferator-activated Receptor α Negatively Regulates the Vascular Inflammatory Gene Response by Negative Cross-talk with Transcription Factors NF-κB and AP-1

Philippe Delerive, Karolien De Bosscher, Sandrine Besnard et al. · Journal of Biological Chemistry · 1999 · 1.1K citations · Full text

Life Sciences, Cell Biology, Physiology +17