Publication | Closed Access
2-Amino-4-aryl thiazole: a promising scaffold identified as a potent 5-LOX inhibitor
24
Citations
31
References
2016
Year
PharmacotherapyPromising Lead MoleculeChemical BiologyPharmaceutical ChemistryTranslational PharmacologyAllergy TreatmentMolecular PharmacologyMedicinal ChemistryPromising Scaffold2-Amino-4-aryl ThiazolePotent 5-Lox InhibitorAllergyBiochemistryMechanism Of ActionPharmacological AgentDrug DevelopmentPharmacologyMarketed DrugNatural SciencesRational Drug DesignClinical PharmacologyMedicineDrug Discovery
Human 5-lipoxygenase (5-LOX) is a target for asthma and allergy treatment. Zileuton is the only marketed drug targeting this enzyme (IC<sub>50</sub>∼ 1 μM). The current study identifies a promising lead molecule which could be improved to match the activity of zileuton.
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