Concepedia

Facile synthesis of 4<i>H</i>-chromene derivatives via base-mediated annulation of <i>ortho</i>-hydroxychalcones and 2-bromoallyl sulfones

Srinivas Thadkapally, Athira C Kunjachan, Rajeev S. Menon

Beilstein Journal of Organic Chemistry · 2016 · 19 citations · 23 references

DOIFull text

Open access

Concepts

Abstract

The cesium carbonate-mediated reaction of 2-bromoallyl sulfones and ortho-hydroxychalcones furnished 3-arylsulfonyl-4H-chromene derivatives in 58-67% yield (18 examples). 2-Bromoallyl sulfones functioned as synthetic surrogates for allenyl sulfones in the reaction.

References

23

Structure-based discovery of an organic compound that binds Bcl-2 protein and induces apoptosis of tumor cells

Jialun Wang, Dongxiang Liu, Zhijia Zhang et al. · Proceedings of the National Academy of Sciences · 2000 · 1.2K citations

, , +17

Aqua mediated synthesis of substituted 2-amino-4H-chromenes and in vitro study as antibacterial agents

Mazaahir Kidwai, Shilpi Saxena, M.K.R. Khan et al. · Bioorganic & Medicinal Chemistry Letters · 2005 · 445 citations

, , +11

Discovery of 4-Aryl-4<i>H</i>-chromenes as a New Series of Apoptosis Inducers Using a Cell- and Caspase-based High-Throughput Screening Assay. 1. Structure−Activity Relationships of the 4-Aryl Group

William Kemnitzer, John Drewe, Songchun Jiang et al. · Journal of Medicinal Chemistry · 2004 · 279 citations

, , +16

Rhodomyrtone: A new candidate as natural antibacterial drug from Rhodomyrtus tomentosa

Surasak Limsuwan, Erik N. Trip, Thijs R. H. M. Kouwen et al. · Phytomedicine · 2009 · 184 citations

, , +10

The synthesis of chromenes, chromanes, coumarins and related heterocycles via tandem reactions of salicylic aldehydes or salicylic imines with α,β-unsaturated compounds

Yong‐Ling Shi, Min Shi · Organic & Biomolecular Chemistry · 2007 · 163 citations

, , +13