Disturbance of cardiac gene expression and cardiomyocyte structure predisposes Mecp2-null mice to arrhythmias

Rett syndrome is caused by mutations in X-linked MECP2, encoding methyl-CpG-binding protein 2

Ruthie E. Amir, Ignatia B. Van den Veyver, Mimi Wan et al. · Nature Genetics · 1999 · 5K citations

Chromatin, Genome Instability, Transcriptional Regulation +11

MethPrimer: designing primers for methylation PCRs

Long-Cheng Li, Rajvir Dahiya · Bioinformatics · 2002 · 2.8K citations · Full text

A mouse Mecp2-null mutation causes neurological symptoms that mimic Rett syndrome

Jacky Guy, Brian Hendrich, Megan C. Holmes et al. · Nature Genetics · 2001 · 1.6K citations

Knockout Mouse, Molecular Neuroscience, Mendelian Disorder +12

Deficiency of methyl-CpG binding protein-2 in CNS neurons results in a Rett-like phenotype in mice

Richard Z. Chen, Schahram Akbarian, Matthew Tudor et al. · Nature Genetics · 2001 · 1.3K citations

Synaptic Plasticity, Molecular Neuroscience, Developmental Biology +13

Multipotent Flk-1+ Cardiovascular Progenitor Cells Give Rise to the Cardiomyocyte, Endothelial, and Vascular Smooth Muscle Lineages

Steven Kattman, Tara L. Huber, Gordon Keller · Developmental Cell · 2006 · 725 citations · Full text

Cardiac Muscle, Cardiomyopathy, Developmental Biology +12