Phase I and pharmacokinetic study of irinotecan (CPT-11) administered daily for three consecutive days every three weeks in patients with advanced solid tumors

Reporting results of cancer treatment

A. B. Miller, Barth Hoogstraten, M. Staquet et al. · Cancer · 1981 · 7.8K citations

World Health Organization, Medicine, Cancer Management +13

Camptothecin induces protein-linked DNA breaks via mammalian DNA topoisomerase I.

Y H Hsiang, Robert Hertzberg, Sidney M. Hecht et al. · Journal of Biological Chemistry · 1985 · 2.3K citations · Full text

Chromatin, Genome Instability, Dna Damage +12

Arrest of replication forks by drug-stabilized topoisomerase I-DNA cleavable complexes as a mechanism of cell killing by camptothecin.

Y H Hsiang, M G Lihou, Leroy F. Liu · PubMed · 1989 · 1K citations

Chromatin, Genome Instability, Fork Breakage +9

Intracellular roles of SN-38, a metabolite of the camptothecin derivative CPT-11, in the antitumor effect of CPT-11.

Yasuyoshi Kawato, Masashi Aonuma, Yasuhide Hirota et al. · PubMed · 1991 · 874 citations

Medicinal Chemistry, Chemoprevention Strategy, Camptothecin Derivative Cpt-11 +12

Identification of mammalian DNA topoisomerase I as an intracellular target of the anticancer drug camptothecin.

Yaw Huei Hsiang, Leroy F. Liu · PubMed · 1988 · 844 citations

Genome Instability, Anticancer Drug Camptothecin, Intracellular Target +13