Concepedia

Pt(<scp>iv</scp>) derivatives of cisplatin and oxaliplatin with phenylbutyrate axial ligands are potent cytotoxic agents that act by several mechanisms of action

Raji Raveendran, Jeremy Phillip Braude, Ezequiel Wexselblatt, Vojtěch Novohradský, Olga Stuchlíková, Viktor Brabec, Valentina Gandin, Dan Gibson

Chemical Science · 2016 · 180 citations · 37 references

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Concepts

Abstract

]. These compounds combine multiple effects such as efficient uptake of both Pt and PhB with DNA binding, HDAC inhibition and activation of caspases to effectively kill cancer cells.

References

37

The status of platinum anticancer drugs in the clinic and in clinical trials

Nial Wheate, Shonagh Walker, Gemma E. Craig et al. · Dalton Transactions · 2010 · 1.6K citations

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FDA Approval Summary: Vorinostat for Treatment of Advanced Primary Cutaneous T-Cell Lymphoma

Bhupinder Mann, John R. Johnson, Martin H. Cohen et al. · The Oncologist · 2007 · 1.4K citations · Full text

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Characterization of the p53 tumor suppressor pathway in cell lines of the National Cancer Institute anticancer drug screen and correlations with the growth-inhibitory potency of 123 anticancer agents.

P M O'Connor, Joany Jackman, I Bae et al. · PubMed · 1997 · 882 citations

, , +15

Platinum(IV) antitumour compounds: their bioinorganic chemistry

Matthew D. Hall, Trevor W. Hambley · Coordination Chemistry Reviews · 2002 · 617 citations

, , +10

Potent histone deacetylase inhibitors built from trichostatin A and cyclic tetrapeptide antibiotics including trapoxin

Ryohei Furumai, Yasuhiko Komatsu, Norikazu Nishino et al. · Proceedings of the National Academy of Sciences · 2000 · 412 citations · Full text

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